2-Methoxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)isonicotinic acid is an organic compound with the chemical formula C14H18N2O6. It is a solid and is often used as an intermediate in the synthesis of organic compounds.
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: approx. 115-120°C
-Solubility: Soluble in organic solvents such as chloroform, methanol and dimethylformamide, slightly soluble in water.
Use:
2-Methoxy-3-({[(2-methyl-2-proxy) oxy]carbonyl}amino)isonicotinic acid can be used as a protecting group in organic synthesis.
-It can be used as a pharmaceutical intermediate for the synthesis of some biologically active compounds.
Preparation Method:
2-Methoxy-3-({[(2-methyll-2-proxy) oxy]carbonyl}amino)isonicotinic acid synthesis method can include the following steps:
1. reacting isonicotinic acid with dimethyl ketone to obtain 2-methoxyisonicotinic acid.
2.2-Methoxy isonicotinic acid is reacted with chloroacetyl chloride to obtain 2-(2-chloroacetyl) isonicotinic acid.
3.2-(2-chloroacetyl) isonicotinic acid is reacted with methanol and potassium bicarbonate to obtain 2-Methoxy-3-({[(2-methyl-2-proxy) oxy]carbonyl}amino)isonicotinic acid.